1882, in the meaning defined above
earlier, "fluid from cowpox pustules used in inoculation," noun use of vaccine "of cowpox" (in the phrases vaccine disease, vaccine matter), borrowed from New Latin vaccina (in variolae vaccinae "cowpox"), going back to Latin, feminine of vaccīnus "of or from a cow," from vacca "cow" (perhaps akin to Sanskrit vaśā "cow") + -īnus -ine entry 1; in extended sense, "preparation of organisms administered to produce immunity," in part borrowed from French vaccin, masculine derivative of vaccine "cowpox, matter from cowpox pustules," borrowed from New Latin or English
vaccine
nounvaccine
nounvaccine
noun