Conclusion:The new synthesis process of tramadol hydrochloride is practicable.

结论：盐酸曲马多的新合成方法切实可行。

Objective: To study the Stereoselectivity in trans-tramadol ( ±)-trans T metabolism and trans-O-demethyltramadol ( ±)-Ml formation in rat liver microsomes in vitro.

目的：研究手性药物反式曲马朵(±)-trans T代谢及其活性代谢物反式O-去甲基曲马朵(±)-M1生成的立体选择性。

Results:In the 223 samples,there were nicotinamide(180samples,80.7%),coffeine(111 samples,49.8%),acetaminophenol(49samples,22.0%),amidopyrine(41 samples 18.4%),theophylline(20samples,8.97%),piracetam(25samples,11.2%);phenacetin(35samples,15.7%),sleeping potion(34samples,15.2%),clozapine(13samples,5.83%),methamphetamine(16samples,7.17%),ketamine(2samples,0.9%) ;tramadol(1 sample,0.45%).

结果:在223例海洛因毒品中检出的有机稀释剂有烟酰胺180例(80.7%)、咖啡因111例(49.8%)、扑热息痛49例(22.0%)、氨基比林41例(18.4%)、茶碱20例(8.97%)、脑复康25例(11.2%)、非那西丁35例(15.7%)、安眠镇静药34例(15.2%)、氯氮平13例(5.83%)、甲基苯丙胺16例(7.17%)、氯胺酮2例(0.90%)、曲马多1例(0.45%);未检出有机稀释剂的有32例占14.3%。