Objective To observe the behavior changes and connexin 32(CX32),connexin 43(CX43)expressions in hippocampus and the effect of carbenoxolone on their expression in epileptic immature rats induced by lithium-pilocarpine.

目的在建立锂-匹罗卡品点燃幼鼠癫模型的基础上,观察各组大鼠行为学改变、各时间点海马缝隙连接蛋白CX32、CX43的表达变化及甘珀酸的干预作用。

Carbenoxolone, as an antiulcer medicine, was found can inhibit gap junctional intercellular communication. Carbenoxolone have been shown to depress epileptiform activity in vitro studies.

生胃酮是一种抗胃溃疡药,但最近发现有阻断缝隙连接的功能,并在体外试验中发现能抑制痫样放电。