heterotopic chondrogenesis异位成软骨
exvivo chondrogenesis体外软骨形成
Chondrogenesis stimulating factors软骨形成刺激因子
Objective To investigate the effect and possible mechanism of poly-L-lysine(PL) on promoting chondrogenesis in vitro.
目的：探讨多聚左旋赖氨酸(poly-L-lysine，PL)对软骨形成的促进作用及其可能机制。
Our research showed:different concentration of TGF-β_1 had different effects in chondrogenesis,10μg/L was the best concentration for chondrogenesis.
研究表明:不同浓度的TGF-β_1对于促进MSCs的成软骨分化作用效果不同,10μg/L为促进软骨分化的最佳浓度。
Human MSCs regenerated slower in chondrogenesis,and the shape changed gradually,turned to be broad,flat,polygon and multi-branch.
成软骨诱导过程中人MSCs增殖减慢,形态逐渐发生改变,向扁平宽大、多角多分支形态变化。
参考来源 - SOX9基因在软骨发育过程中的表达谱分析及其质粒转染鼠骨髓基质细胞的实验研究 Assessment of the expression profile of SRYThe strongest expression was observed in pituitary,cartilage and gonad,whereas the lowest was seen in spleen,thymus and lymph,suggesting that Sox9 protein plays important roles in porcine gonad,brain and chondrogenesis development function.
在性腺和脑组织表达水平最高,而在脾、胸腺、淋巴组织表达水平最低,说明了Sox9基因在猪性腺、脑的发育以及软骨发生的功能与作用。
参考来源 - 成纤维细胞生长因子受体3（FGFR3）在小鼠骨形成过程中作用和机制的研究