A convenient method of synthesis of melatonin using1,3-dibromopropare as main starting material was studied. It consisted of five steps including diazotization, Fischer cyclization, ring opening, decarboxylation, and acetylation with 27.8% total yield.

研究了一种合成松果体素的简便方法，以1，3-二溴丙烷为起始原料，经过重氮化，Fischer环化，开环和脱羧以及乙酰化等5步反应，制备得到松果体素，总收率达27.8％，并研究了合成过程中的Fischer反应。

There are three parts in this thesis. Two new and simple strategies were established for fabricating of deoxyribonucleic acid(DNA) electrochemical biosensor based on covalent immobilization of probe NH2–ssDNA by sol–gel coupling (the first chapter) and diazotization-coupling (the second chapter).

本论文分三部分,第一、第二部分利用溶胶-凝胶自组装法和偶氮化法共价固定NH2–ssDNA,研制了两种新型的DNA传感器;第三部分是在第二部分的基础上,在电极表面共价固定硫堇分子,制备了一种无酶无试剂型过氧化氢传感器。