Synthesis 3, 5-dihydroxytoluene by ethyl acetoacetate and diketene as material ( yield 6%), by 3-methyl-4-chlorophenol and KOH as material (yield 30-40%) respectively, It was solved for product separation and purify.

分别以乙酰乙酸乙酯与双乙烯酮为原料(收率6％)、3-甲基-4-氯苯酚与氢氧化钾为原料(收率30-40％)合成了3，5-二羟基甲苯，解决了产品分离纯化问题。

The optimum conditions of acylation was as follows:reaction temperature was 80~85℃. The mole ratio of diketene and 2-methoxy- ethanol was 1:1; reaction time was 2.5~3h and the optimum catalyts was triethylamine.

在该路线中,双乙烯酮酯化反应的最佳反应条件为:反应温度为80~85℃;双乙烯酮与乙二醇单甲醚的摩尔比为1:1;反应时间为2.5~3h;催化剂为三乙胺。