enol lactonization烯醇内酯化反应
Yamaguchi lactonizationYamaguchi大环化
acid-lactonization酸内酯化
the second lactonization二次内酯化
Yamaguchi's macro-lactonizationYamaguchi内酯化
Simvastatin is a new cholesterol lowering agent that id partially synthesized from lovastatin. Simvastatin is an inactive lactonization precursor pharmaceutical, it operate by active metabolites or its derivatives via liver hydrolyzation.
辛伐他汀是通过洛伐他汀半合成得到的降胆固醇药，它是一种非活性的内酯化前体药物，通过肝脏水解成活性代谢产物或其衍生物而起作用，用于治疗高胆固醇血症。
参考来源 - 辛伐他汀的合成研究