Buddloside Linarin蒙花苷
linarin isovalerate异戊酸酯
The elimination rate constant (Ke) and the biological half-life (T1/2) was 1.02 h-1 and 1.12 h, respectively. While those parameters for linarin (173.2μg/kg) were 0.42 h, 134.9 ng/ml, 188.9 ng·h·mL-1, 0.67 h-1 and 1.08 h, respectively.
蒙花苷在0.42h达峰,峰浓度Cmax为134.9ng·mL-1,血药浓度-时间曲线下面积AUC0-∞值为188.9ng·h·mL-1,体内消除速率常数Ke和生物半衰期T1/2分别为0.67h-1和1.08h。
参考来源 - 野菊花注射液质量控制方法与相关成分药动学研究